Publications

2012

 
   


Alternative Testing Strategies: Progress Report 2012 & AXLR8-3 Workshop Report on a 'Roadmap to Next Generation Safety Testing Under Horizon 2020'
Berlin: AXLR8 Consortium, 288 pp., 2012

The AXLR8 project: New tools for chemical safety assessment
Public Service Review: European Union: Issue 23

SEURAT-1 Annual Report 2012
France: COACH Consortium, 2012

Stemming the toxic tide: How to screen using stem cells
Chi KR
The Scientist, September 2012

2011

Alternative Testing Strategies: Progress Report 2011 & AXLR8-2 Workshop Report on a 'Roadmap to Innovative Toxicity Testing'
Berlin: AXLR8 Consortium, 360 pp., 2011

SEURAT-1 Annual Report
France: COACH Consortium, 304 pp., 2011

A Critical Evaluation of the 2011 ECHA Reports on Compliance with the REACH and CLP Regulations and on the Use of Alternatives to Testing on Animals for Compliance with the REACH Regulation
Spielmann H, Sauer UG, Mekenyan O
Altern Lab Anim. 39, 481-93, 2011

The validated embryonic stem cell test to predict embryotoxicity in vitro
Seiler AEM, Spielmann H.
Nature Protocols 6, 961-78, 2011

Estimating toxicity-related biological pathway altering doses for high-throughput chemical risk assessment
Judson RS, Kavlock RJ, Setzer RW, et al.
Chem Res Toxicol. 2011; dx.doi.org/10.1021/tx100428e

Toxicity testing and safety assessment in the 21st century: Creating a research program to accelerate change
Andersen M
AltTox.org 2011

Discriminating classes of developmental toxicants using gene expression profiling in the embryonic stem cell test
van Dartel DAM, Pennings JLA, Robinson JF, et al.
Toxicol Lett. 201, 143-51, 2011 

Predictive model of rat reproductive toxicity from ToxCast high throughput screening
Martin MT, Knudsen TB, Erif DM, et al.
Biol Reprod. 2011; doi biolreprod.111.090977

2010

Alternative Testing Strategies: Progress Report 2010 
Berlin: AXLR8 Consortium, 298 pp., 2010

Final Report - Workshop on Computational Chemistry and Systems Biology - "Harnessing the Chemistry of Life: Revolutionising Toxicology"
European Partnership on Alternative Approaches to Animal Testing
5-7 July 2010, Brussels, Belgium

A look inside the framework: EU funding priorities and criteria in the health theme of the co-operation programme
Draghia-Akli R
Bioessays 32, 923-5, 2010

 Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment
Ankley GT, Bennett RS, Erickson RJ, et al.
Environ Toxicol Chem. 29, 730-41, 2010

A mechanistic redefinition of adverse effects – a key step in the toxicity testing paradigm shift
Boekelheide K, Anderson ME
ALTEX 27, 243-52, 2010

NextGen Program Synopsis & Draft Workshop Report
US EPA, 2010

Computational systems biology and dose-response modeling in relation to new directions in toxicity testing
Zhang Q, Bhattacharya S, Andersen ME, et al.
J Toxicol Environ Hlth B. 12, 253-76, 2010 

 Biokinetic modeling and in vitro-in vivo extrapolations
Blaauboer BJ
J Toxicol Environ Hlth B. 12, 242-52, 2010

 Public databases supporting computational toxicology
Judson R
J Toxicol Environ Hlth B. 12, 218-31, 2010.

Predicting human developmental toxicity of pharmaceuticals using human embryonic stem cells and metabolomics
West PR, Weir AM, Smith AM, et al.
Toxicol Appl Pharmacol. 2010; doi:10.1016/j.taap.2010.05.007 

 Endocrine profiling and prioritisation of environmental chemicals using ToxCast data
Reif DM, Martin MT, Tan SW, et al.
Environ Hlth Perspect. 118, 2-8, 2010

Metabolic activation capacity by primary hepatocytes expands the applicability of the embryonic stem cell test as alternative to experimental animal testing
Hettwer M, Reis-Fernandes MA, Iken M, et al.
Reprod Toxicol. 2010; doi:10.1016/j.reprotox.2010.01.009 

 Protein biomarkers for in vitro testing of embryotoxicity
Groebe K, Hayess K, Klemm-Manns M, et al.
J Proteome Res. 2010; 9, 5727-38, 2010 

2009

Alternative Testing Strategies: Progress Report 2009 
Genomics & Biotechnology for Health - EUR 23886
Luxembourg: Office for Official Publications of the European Communities, 280 pp., 2009

Genetic and environmental pathways to complex diseases
Gohlke JM, Thomas R, Zhang Y, et al.
BMC Syst Biol. 3, 46-61, 2009

The Environmental Protection Agency's Strategic Plan for Evaluating the Toxicity of Chemicals
US EPA, 2009

The way forward in reproductive/developmental toxicity testing
Spielmann, H
ATLA 37, 641-56, 2009

Bringing toxicology into the 21st century: A global call to action
Seidle T, Stephens ML.
Toxicol In Vitro 23, 1576-9, 2009 

Toxicity testing in the 21st century: Implications for human health risk assessment
Krewski D, Andersen ME, Mantus E, Zeise L
Risk Anal. 29, 474-9, 2009

Biologically relevant exposure science for 21st century toxicity testing
Hubal EA
Toxicol Sci. 111, 226-32 2009

Toxicity testing in the 21st century: Bringing the vision to life
Andersen ME, Krewski D
Toxicol Sci. 107, 324-30, 2009

2008 & prior

Alternative Testing Strategies: Progress Report 2008
Genomics & Biotechnology for Health – EUR 22846
Luxembourg: Office for Official Publications of the European Communities, 96 pp., 2008

New Perspectives on Safety: Workshop Report
European Partnership on Alternative Approaches to Animal Testing (EPAA)
Brussels, April 2008

Toxicity Testing in the Twenty-First Century: A Vision and a Strategy
US National Research Council Committee on Toxicity Testing and Assessment of Environmental Agents
National Academy Press, 2007

A National Toxicology Program for the 21st Century
US National Toxicology Program, Research Triangle Park, NC, 2004

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